Environmental and anthropogenic factors synergistically affect space use of jaguars

Environmental and anthropogenic factors synergistically affect space use of jaguars

Large terrestrial carnivores have undergone some of the most important inhabitants declines and vary reductions of any species, which is of concern as they’ll have massive results on ecosystem dynamics and operate.1-4 The jaguar (Panthera onca) is the apex predator all through the bulk of the Neotropics; nonetheless, its distribution has been diminished by >50% and it survives in more and more remoted populations.
Consequently, the range-wide administration of the jaguar relies upon upon sustaining core populations related by way of multi-national, transboundary cooperation, which requires understanding the motion ecology and space use of jaguars all through their vary.6-8 Using GPS telemetry information for 111 jaguars from 13 ecoregions throughout the 4 biomes that represent the bulk of jaguar habitat, we examined the landscape-level environmental and anthropogenic factors associated to jaguar dwelling vary dimension and motion parameters.
Home vary dimension decreased with growing web productiveness and forest cowl and elevated with growing street density. Speed decreased with growing forest cowl with no sexual variations, whereas males had extra directional actions, however tortuosity in actions was not associated to any panorama factors. We demonstrated a synergistic relationship between landscape-scale environmental and anthropogenic factors and jaguars’ spatial wants, which has purposes to the conservation technique for the species all through the Neotropics.
Using large-scale collaboration, we overcame limitations from small pattern sizes typical in massive carnivore analysis to offer a mechanism to judge habitat high quality for jaguars and an inferential modeling framework adaptable to the conservation of different massive terrestrial carnivores.

Proteomic Analysis of Histone Crotonylation Suggests Diverse Functions in Myzus persicae

Myzus persicae is one of crucial financial pests of cultivated crops. In the current examine, we used an built-in method involving high-performance liquid chromatography fractionation, affinity enrichment, and mass spectrometry-based proteomics to hold out a complete proteomic evaluation of lysine crotonylation in M. persicae. Altogether, 7530 lysine crotonylation websites have been recognized in 2452 protein teams.
Intensive bioinformatic analyses have been then carried out to annotate these lysine crotonylated targets recognized in phrases of Gene Ontology annotation, area annotation, subcellular localization, Kyoto Encyclopedia of Genes and Genomes pathway annotation, practical cluster evaluation, and so forth. Analysis outcomes confirmed that lysine-crotonylated proteins have been concerned in lots of organic processes, such because the amino acid metabolism, aminoacyl-tRNA biosynthesis, spliceosomes, ribosomes, and so forth.
Notably, the interplay community confirmed that there have been 199 crotonylated proteins concerned within the amino acid metabolism and quite a few crotonylation targets related to fatty acid biosynthesis and degradation. The outcomes present a system-wide view of all the M. persicae crotonylome and a wealthy information set for practical evaluation of crotonylated proteins on this economically vital pest, which marks an vital starting for the additional analysis.
Environmental and anthropogenic factors synergistically affect space use of jaguars

Advancing Undergraduate Synthetic Biology Education: Insights from a Canadian iGEM Student Perspective

The final twenty years have seen vigorous exercise in artificial biology analysis and ever-increasing purposes of its applied sciences. However, pedagogical analysis pertaining to instructing artificial biology is scarce, particularly when in comparison with different science and engineering disciplines. Within Canada there are solely three universities that provide artificial biology applications; two of that are on the undergraduate stage.
Rather than happen in formal tutorial settings, many Canadian undergraduate college students are launched to artificial biology by way of participation within the annual International Genetically Engineered Machine (iGEM) competitors. Although the iGEM competitors has had a transformative affect on artificial biology coaching in different nations, the affect in Canada has been comparatively modest.
Consequently, the iGEM competitors remains to be a significant setting for artificial biology schooling in Canada. To promote additional improvement of artificial biology schooling, we surveyed undergraduate college students from the Canadian iGEM design groups of 2019. We extracted insights from these information utilizing qualitative evaluation to offer suggestions for greatest instructing practices in artificial biology undergraduate schooling, which we describe by way of our proposed Framework for Transdisciplinary Synthetic Biology Education (FTSBE).

You May Read This: 4-Arm PEG-Acrylate is a multiarm abx085084 PEG derivative with acrylate groups at each terminal of the four arms connected to one pentaerythritol core. The 4arm-PEG acrylate can be used for radical initiator or UV light-induced polymerization to synthesize PEG hydrogel.

Curated Data In – Trustworthy In Silico Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing

New Approach Methodologies (NAMs) that make use of synthetic intelligence (AI) for predicting adversarial results of chemical compounds have generated optimistic expectations as options to animal testing. However, the foremost underappreciated problem in growing strong and predictive AI fashions is the affect of the standard of the enter information on the mannequin accuracy. Indeed, poor information reproducibility and high quality have been incessantly cited as factors contributing to the disaster in biomedical analysis, in addition to comparable shortcomings within the fields of toxicology and chemistry.
In this text, we overview the newest efforts to enhance confidence within the robustness of toxicological information and examine the affect that information curation has on the arrogance in mannequin predictions. We additionally current two case research demonstrating the impact of information curation on the efficiency of AI fashions for predicting pores and skin sensitisation and pores and skin irritation.

ASAH2 Polyclonal Antibody

A72338-050 50 ul
EUR 302.5

ASAH2 Polyclonal Antibody

A72338-100 100 ul
EUR 423.5

ASAH2 Polyclonal Antibody

A72339-050 50 ul
EUR 302.5

ASAH2 Polyclonal Antibody

A72339-100 100 ul
EUR 423.5

ASAH2 Rabbit pAb

A12596-100ul 100 ul
EUR 369.6

ASAH2 Rabbit pAb

A12596-200ul 200 ul
EUR 550.8

ASAH2 Rabbit pAb

A12596-20ul 20 ul
EUR 219.6

ASAH2 Rabbit pAb

A12596-50ul 50 ul
EUR 267.6

ASAH2 Rabbit pAb

A7985-100ul 100 ul
EUR 369.6

ASAH2 Rabbit pAb

A7985-200ul 200 ul
EUR 550.8

ASAH2 Rabbit pAb

A7985-20ul 20 ul
EUR 219.6

ASAH2 Rabbit pAb

A7985-50ul 50 ul
EUR 267.6

ASAH2 antibody

70R-12124 100 ug
EUR 483.6
Description: Rabbit polyclonal ASAH2 antibody

ASAH2 Antibody

3828-100
EUR 379.2

ASAH2 Antibody

3828-30T
EUR 175.2

ASAH2 Antibody

4743-002mg 0.02 mg
EUR 206.18
Description: ASAH2 Antibody: Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface, catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pH of 6.5-8.5. ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger. ASAH2 is ubiquitously expressed primarily expressed with higher levels in the intestine, kidney, skeletal muscle and heart. Recent studies indicate that ASAH2 encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract.

ASAH2 Antibody

4743-01mg 0.1 mg
EUR 523.7
Description: ASAH2 Antibody: Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface, catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pH of 6.5-8.5. ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger. ASAH2 is ubiquitously expressed primarily expressed with higher levels in the intestine, kidney, skeletal muscle and heart. Recent studies indicate that ASAH2 encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract.

ASAH2 Antibody

36240-100ul 100ul
EUR 302.4

ASAH2 Antibody

24731-100ul 100ul
EUR 468

ASAH2 Antibody

1-CSB-PA002170EA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against ASAH2. Recognizes ASAH2 from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:100-1:500, IF:1:50-1:500

ASAH2 Antibody

1-CSB-PA076840
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against ASAH2. Recognizes ASAH2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

ASAH2 Antibody

DF15667 100ul
EUR 420

ASAH2 Antibody

1-CSB-PA133826
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against ASAH2. Recognizes ASAH2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

ASAH2 Antibody

F40044-0.08ML 0.08 ml
EUR 165

ASAH2 Antibody

F40044-0.4ML 0.4 ml
EUR 379

ASAH2 Polyclonal Antibody, HRP Conjugated

A62107-050 50 ul
EUR 302.5

ASAH2 Polyclonal Antibody, HRP Conjugated

A62107-100 100 ul
EUR 423.5

ASAH2 Polyclonal Antibody, FITC Conjugated

A62108-050 50 ul
EUR 302.5

ASAH2 Polyclonal Antibody, FITC Conjugated

A62108-100 100 ul
EUR 423.5

ASAH2 Polyclonal Antibody, Biotin Conjugated

A62109-050 50 ul
EUR 302.5

ASAH2 Polyclonal Antibody, Biotin Conjugated

A62109-100 100 ul
EUR 423.5

ASAH2 Polyclonal Antibody, HRP Conjugated

A62107
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

ASAH2 Polyclonal Antibody, FITC Conjugated

A62108
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

ASAH2 Polyclonal Antibody, Biotin Conjugated

A62109
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

ASAH2 Conjugated Antibody

C36240 100ul
EUR 476.4

Anti-ASAH2 antibody

STJ114470 100 µl
EUR 332.4

Anti-ASAH2 antibody

STJ110292 100 µl
EUR 332.4

ASAH2 Peptide

4743P 0.05 mg
EUR 197.7
Description: (CT) ASAH2 peptide

ASAH2 siRNA

20-abx900469
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

ASAH2 siRNA

20-abx908269
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

ASAH2 siRNA

20-abx908270
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

ASAH2 Antibody, HRP conjugated

1-CSB-PA002170EB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against ASAH2. Recognizes ASAH2 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

ASAH2 Antibody, FITC conjugated

1-CSB-PA002170EC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against ASAH2. Recognizes ASAH2 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

ASAH2 Antibody, Biotin conjugated

1-CSB-PA002170ED01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against ASAH2. Recognizes ASAH2 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

ASAH2 Blocking Peptide

3828BP-50
EUR 183.6

ASAH2 Blocking Peptide

33R-10941 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ASAH2 antibody, catalog no. 70R-12124

ASAH2 cloning plasmid

CSB-CL865115HU-10ug 10ug
EUR 568.8
Description: A cloning plasmid for the ASAH2 gene.

Human ASAH2 shRNA Plasmid

20-abx961153
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse ASAH2 shRNA Plasmid

20-abx974501
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Rat ASAH2 shRNA Plasmid

20-abx987160
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

ASAH2 Recombinant Protein (Human)

RP036760 100 ug Ask for price

ASAH2 Recombinant Protein (Rat)

RP191108 100 ug Ask for price

ASAH2 Recombinant Protein (Mouse)

RP117410 100 ug Ask for price

N-Acylsphingosine Amidohydrolase 2 (ASAH2) Antibody

20-abx007107
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

N-Acylsphingosine Amidohydrolase 2 (ASAH2) Antibody

abx025039-400ul 400 ul
EUR 627.6

N-Acylsphingosine Amidohydrolase 2 (ASAH2) Antibody

abx025039-80l 80 µl
EUR 343.2

N-Acylsphingosine Amidohydrolase 2 (ASAH2) Antibody

20-abx303129
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

N-Acylsphingosine Amidohydrolase 2 (ASAH2) Antibody

20-abx214010
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

N-Acylsphingosine Amidohydrolase 2 (ASAH2) Antibody

20-abx214011
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

N-Acylsphingosine Amidohydrolase 2 (ASAH2) Antibody

20-abx173712
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

N-Acylsphingosine Amidohydrolase 2 (ASAH2) Antibody

20-abx177710
  • EUR 1446.00
  • EUR 693.60
  • 1 mg
  • 200 ug

N-Acylsphingosine Amidohydrolase 2 (ASAH2) Antibody (HRP)

20-abx303130
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

N-Acylsphingosine Amidohydrolase 2 (ASAH2) Antibody (FITC)

20-abx303131
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

N-Acylsphingosine Amidohydrolase 2 (ASAH2) Antibody (Biotin)

20-abx303132
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

ASAH2 ELISA Kit (Human) (OKCD01831)

OKCD01831 96 Wells
EUR 997.2
Description: Description of target: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.31 ng/mL

Asah2 ORF Vector (Rat) (pORF)

ORF063704 1.0 ug DNA
EUR 607.2

ASAH2 ORF Vector (Human) (pORF)

ORF012254 1.0 ug DNA
EUR 424.8

Asah2 ORF Vector (Mouse) (pORF)

ORF039138 1.0 ug DNA
EUR 607.2

Asah2 sgRNA CRISPR Lentivector set (Rat)

K7087001 3 x 1.0 ug
EUR 406.8

ASAH2 sgRNA CRISPR Lentivector set (Human)

K0130501 3 x 1.0 ug
EUR 406.8

Asah2 sgRNA CRISPR Lentivector set (Mouse)

K3499601 3 x 1.0 ug
EUR 406.8

Human N-Acylsphingosine Amidohydrolase 2 (ASAH2) Protein

20-abx654471
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse ASAH2 (Neutral ceramidase) ELISA Kit (CUSTOM)

ELI-34287m 96 Tests
EUR 1038

Human ASAH2 (Neutral ceramidase) ELISA Kit (CUSTOM)

ELI-34330h 96 Tests
EUR 988.8

Rat ASAH2 (Neutral ceramidase) ELISA Kit (CUSTOM)

ELI-48960r 96 Tests
EUR 1063.2

Asah2 sgRNA CRISPR Lentivector (Rat) (Target 1)

K7087002 1.0 ug DNA
EUR 184.8

Asah2 sgRNA CRISPR Lentivector (Rat) (Target 2)

K7087003 1.0 ug DNA
EUR 184.8

Asah2 sgRNA CRISPR Lentivector (Rat) (Target 3)

K7087004 1.0 ug DNA
EUR 184.8

ASAH2 sgRNA CRISPR Lentivector (Human) (Target 1)

K0130502 1.0 ug DNA
EUR 184.8

ASAH2 sgRNA CRISPR Lentivector (Human) (Target 2)

K0130503 1.0 ug DNA
EUR 184.8

ASAH2 sgRNA CRISPR Lentivector (Human) (Target 3)

K0130504 1.0 ug DNA
EUR 184.8

Asah2 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3499602 1.0 ug DNA
EUR 184.8

Asah2 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3499603 1.0 ug DNA
EUR 184.8

Asah2 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3499604 1.0 ug DNA
EUR 184.8

ASAH2 Protein Vector (Mouse) (pPB-C-His)

PV156550 500 ng
EUR 1278

ASAH2 Protein Vector (Mouse) (pPB-N-His)

PV156551 500 ng
EUR 1278

ASAH2 Protein Vector (Mouse) (pPM-C-HA)

PV156552 500 ng
EUR 1278

ASAH2 Protein Vector (Mouse) (pPM-C-His)

PV156553 500 ng
EUR 1278

ASAH2 Protein Vector (Human) (pPB-C-His)

PV049013 500 ng
EUR 577.2

ASAH2 Protein Vector (Human) (pPB-N-His)

PV049014 500 ng
EUR 577.2

ASAH2 Protein Vector (Human) (pPM-C-HA)

PV049015 500 ng
EUR 577.2

ASAH2 Protein Vector (Human) (pPM-C-His)

PV049016 500 ng
EUR 394.8

ASAH2 3'UTR Luciferase Stable Cell Line

TU001220 1.0 ml
EUR 1825.2

Asah2 3'UTR Luciferase Stable Cell Line

TU102183 1.0 ml Ask for price

ASAH2 3'UTR GFP Stable Cell Line

TU051220 1.0 ml
EUR 1825.2

Asah2 3'UTR Luciferase Stable Cell Line

TU200951 1.0 ml Ask for price

Asah2 3'UTR GFP Stable Cell Line

TU250951 1.0 ml Ask for price

Asah2 3'UTR GFP Stable Cell Line

TU152183 1.0 ml Ask for price

ASAH2 Protein Vector (Human) (pPB-His-MBP)

PV324138 500 ng
EUR 577.2

ASAH2 Protein Vector (Human) (pPB-His-GST)

PV324139 500 ng
EUR 577.2

ASAH2 Protein Vector (Rat) (pPB-C-His)

PV254814 500 ng
EUR 1399.2

ASAH2 Protein Vector (Rat) (pPB-N-His)

PV254815 500 ng
EUR 1399.2

ASAH2 Protein Vector (Rat) (pPM-C-HA)

PV254816 500 ng
EUR 1399.2

ASAH2 Protein Vector (Rat) (pPM-C-His)

PV254817 500 ng
EUR 1399.2

GAPDH Rabbit Polyclonal Antibody

A01021-005ml 0.05ml
EUR 176.4
Description: A polyclonal antibody for detection of GAPDH from Human, Mouse, Rat, Rabbit, Chicken, Monkey, Sheep, Xneous. This GAPDH antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

GAPDH Rabbit Polyclonal Antibody

A01021-02ml 0.2ml
EUR 398.4
Description: A polyclonal antibody for detection of GAPDH from Human, Mouse, Rat, Rabbit, Chicken, Monkey, Sheep, Xneous. This GAPDH antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

GAPDH Rabbit Polyclonal Antibody

A01021-02ml5 0.2ml×5
EUR 1104
Description: A polyclonal antibody for detection of GAPDH from Human, Mouse, Rat, Rabbit, Chicken, Monkey, Sheep, Xneous. This GAPDH antibody is for WB, IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

Vimentin Rabbit Polyclonal Antibody

38104-100ul 100ul
EUR 302.4
We present that, whereas fashions generated with uncurated information had a 7-24% greater appropriate classification fee (CCR), the perceived efficiency was, the truth is, inflated owing to the excessive quantity of duplicates within the coaching set. We assert that information curation is a important step in constructing computational fashions, to assist be certain that dependable predictions of chemical toxicity are achieved by way of use of the fashions.

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